An isoform of AIF1 involved in breast cancer

Table 3 Spearman’s correlation between AIF1v1/v3 expression in breast tumors and breast adipose tissue and variables

Variable	N	Breast tumors		N	Breast adipose tissue
		AIF1v1 expression	AIF1v3 expression		AIF1v1 expression	AIF1v1 expression adjusted*
		Rs (p)	Rs (p)		Rs (p)	Rs (p)
Age (years)	13	*0.65 (0.02)*	0.52 (0.06)	74	0.16 (0.16)	–
Weight (kg)	13	0.05 (0.85)	0.17 (0.58)	74	*0.25 (0.03)*	0.22 (0.06)
BMI (kg/m²)	13	0.22 (0.47)	0.30 (0.32)	74	0.19 (0.09)	0.16 (0.16)
Waist-hip ratio	13	0.33 (0.27)	0.37 (0.21)	74	0.23 (0.05)	0.17 (0.14)
Menopausal status	13	0.55 (0.05)	0.08 (0.78)	74	0.19 (0.09)	0.06 (0.57)
Adipose breast area (cm²)	13	0.32 (0.28)	0.27 (0.36)	74	*0.31 (0.008)*	*0.27 (0.02)*
CYP19A1 expression	12	*0.63 (0.03)*	0.39 (0.21)	74	*0.83 (< 0.0001)*	*0.82 (< 0.0001)*
ERα expression	12	0.37 (0.24)	0.08 (0.79)	74	*0.49 (< 0.0001)*	*0.47 (< 0.0001)*
Leptin expression	7	0.39 (0.38)	0.21 (0.64)	74	*0.63 (< 0.0001)*	*0.62 (< 0.0001)*
COX2 expression	7	0.61 (0.15)	*0.79 (0.04)*	73	*0.40 (0.0005)*	*0.40 (0.0006)*
IL-6 expression	7	*0.89 (0.006)*	0.64 (0.12)	74	*0.60 (< 0.0001)*	*0.59 (< 0.0001)*
TNFα expression	6	0.08 (0.87)	− 0.26 (0.62)	64	*0.45 (0.0002)*	*0.47 (< 0.0001)*

Rs Spearman correlation coefficient, p p-value, BMI body mass index, CYP19A1 Cytochrome P450 Family 19 Subfamily A Member 1, Erα estrogen receptor alpha, COX2 cyclooxygenase 2, IL-6 interleukin 6, TNFα tumor necrosis factor alpha
Bold italics text indicates a statistically significant difference with a p-value < 0.05, text in italics shows a p-value between 0.05 and 0.1. Adipose breast area is estimated from mammograms [36]
* Adjusted for age when applicable

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