Fig. 1From: M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathwaya Normal biliary duct gland tissues had regular shapes (arrow; ×200). b Gland tissues of in the cholangiocarcinoma patients were enlarged and disordered (arrow; ×200). c and d Intermediate cholangiocarcinoma invasion of nerve fibers (arrows; c: ×200 and d: ×400). e Cholangiocarcinoma patient survival is related to M3-mAChR expression. f Survival times of patients with cholangiocarcinoma with or without perineural invasion. Scale bars, 200 μmBack to article page