Fig. 5

Overexpression of SKA3 promotes cell cycle progression by activating the PI3K–Akt pathway. a Representative western blot results of proteins related to the PI3K–Akt pathway and the cell cycle in HeLa cells with stable SKA3 overexpression, SKA3 knockdown and control plasmid expression. b Activity of E2F1 in HeLa cells with stable SKA3 overexpression, SKA3 knockdown and control plasmid expression by immunofluorescence. c Representative images of IHC staining for proteins related to the cell cycle (cyclin D1 and CDK4) in tumor sections with SKA3 overexpression, SKA3 knockdown and control plasmid expression (*p < 0.05, **p < 0.01, over-SKA3 vs. control vector. ^#p < 0.05, ^##p < 0.01, SKA3 knockdown vs. control vector)