Fig. 4

The effects of miR-218-5p on cervical cell proliferation, migration, invasion and death. a The expression of miR-218-5p was increased after transfected with miR-218-5p mimics, but miR-218-5p expression reduced after transfected with miR-218-5p inhibitor. *P < 0.05, compared with NC group. b HeLa cells transfected with miR-218-5p mimics showed an obviously decreased in cell proliferation, miR-218-5p inhibitor increased cell proliferation. *P < 0.05, compared with NC group. c Colony formation assay was used to detect HeLa cell proliferation. d Transwell assay was used to detect the invasion ability. e HeLa cells transfected with miR-218-5p mimics showed an obviously decreased in cell invasive, but transfected with miR-218-5p inhibitor showed significantly increasing. *P < 0.05, compared with NC group. f HeLa cells transfected with miR-218-5p mimics showed an obviously decreased in cell migration, but transfected with miR-218-5p inhibitor showed a significant increase. *P < 0.05, compared with NC group. g Wound healing assay was used to detect the migration ability. h Flow cytometry was used to detect the cell death. i MiR-218 mimics induced cell death than NC group; *P < 0.05