Fig. 5
From: MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma
CDK8 siRNA suppresses the proliferation of human glioma U251 cells. a CDK8 siRNA decreased the activity of U251 cells at 48 and 72 h. b CDK8 siRNA inhibited U251 cell proliferation. c Flow cytometric analysis showed the percentage of U251 cells in the G0/G1, S and G2/M phases. G0/G1 phase cells increased after CDK8 siRNA treatment, and S and G2/M phase cells were reduced. d The data showed the percentage of early and late apoptosis after CDK8 siRNA treatment. e The knockdown efficiency of CDK8 siRNA in U251 cells. f CDK8, β-catenin and cyclin D1 protein expression was examined after CDK8 siRNA treatment. *p < 0.01, n = 3