|
Variable
|
Univariate Cox Regression
|
Multivariate Cox Regression
|
|---|
|
HR
|
95% CI
|
P value
|
HR
|
95% CI
|
P value
|
|---|
|
Gender
|
1.187
|
0.841–1.675
|
0.330
| | | |
|
Age at diagnosis
|
1.038
|
1.022–1.053
|
< 0.001
|
0.998
|
0.979–1.018
|
0.875
|
|
WHO Grade
|
3.469
|
2.709–4.443
|
< 0.001
|
1.926
|
1.370–2.709
|
< 0.001
|
|
ADAR3 expression
|
0.356
|
0.284–0.447
|
< 0.001
|
0.571
|
0.430–0.760
|
< 0.001
|
|
MGMT promoter methylation
|
0.529
|
0.374–0.750
|
< 0.001
|
0.665
|
0.444–0.997
|
0.048
|
|
IDH1/2 Mutation status
|
0.229
|
0.159–0.331
|
< 0.001
|
0.637
|
0.370–1.097
|
0.104
|
|
Radiotherapy
|
0.421
|
0.291–0.611
|
< 0.001
|
0.409
|
0.276–0.606
|
< 0.001
|
|
Chemotherapy
|
1.386
|
0.969–1.983
|
0.074
| | | |
- P value < 0.05 was considered statistically significant
- CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase
