ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Table 2 Clinic pathologic factors associated with OS in the Cox hazard regression analysis for glioma patients from the CGGA dataset

Variable	Univariate Cox Regression			Multivariate Cox Regression
Variable	HR	95% CI	P value	HR	95% CI	P value
Gender	1.187	0.841–1.675	0.330
Age at diagnosis	1.038	1.022–1.053	< 0.001	0.998	0.979–1.018	0.875
WHO Grade	3.469	2.709–4.443	< 0.001	1.926	1.370–2.709	< 0.001
ADAR3 expression	0.356	0.284–0.447	< 0.001	0.571	0.430–0.760	< 0.001
MGMT promoter methylation	0.529	0.374–0.750	< 0.001	0.665	0.444–0.997	0.048
IDH1/2 Mutation status	0.229	0.159–0.331	< 0.001	0.637	0.370–1.097	0.104
Radiotherapy	0.421	0.291–0.611	< 0.001	0.409	0.276–0.606	< 0.001
Chemotherapy	1.386	0.969–1.983	0.074

P value < 0.05 was considered statistically significant
CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase

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