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Table 2 Clinic pathologic factors associated with OS in the Cox hazard regression analysis for glioma patients from the CGGA dataset

From: ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Variable Univariate Cox Regression Multivariate Cox Regression
HR 95% CI P value HR 95% CI P value
Gender 1.187 0.841–1.675 0.330    
Age at diagnosis 1.038 1.022–1.053 0.001 0.998 0.979–1.018 0.875
WHO Grade 3.469 2.709–4.443 0.001 1.926 1.370–2.709 < 0.001
ADAR3 expression 0.356 0.284–0.447 < 0.001 0.571 0.430–0.760 < 0.001
MGMT promoter methylation 0.529 0.374–0.750 < 0.001 0.665 0.444–0.997 0.048
IDH1/2 Mutation status 0.229 0.159–0.331 0.001 0.637 0.370–1.097 0.104
Radiotherapy 0.421 0.291–0.611 < 0.001 0.409 0.276–0.606 < 0.001
Chemotherapy 1.386 0.969–1.983 0.074    
  1. P value < 0.05 was considered statistically significant
  2. CI, confidence interval; HR, hazard ratio; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O6-methylguanine-DNA methyltransferase