|
Characteristic
|
Total (60)
|
No. of CIC-3(+) cases (%)a
|
pb
|
|---|
|
Age (years)
|
|
Mean (SD)
|
45.44 ± 11.3
| | |
|
Stage
|
|
I
|
22
|
15 (68.2%)
|
0.016
|
|
II
|
38
|
36 (94.7%)
|
|
Histological grades
|
|
HDSCCc
|
19
|
13 (68.4%)
|
0.029
|
|
MDSCCc
|
25
|
22 (88.0%)
|
|
PDSCCc
|
16
|
16 (100.0%)
|
|
Tumor size (cm)
|
|
D ≤ 4
|
31
|
23 (74.2%)
|
0.039
|
|
D > 4
|
29
|
28 (96.6%)
|
|
Vascular invasion
|
|
Yes
|
21
|
21 (100.0%)
|
0.045
|
|
No
|
39
|
30 (76.9%)
|
|
Invasive interstitial depth
|
|
< 1/2
|
21
|
14 (66.7%)
|
0.012
|
|
≥ 1/2
|
28
|
26 (92.9%)
|
|
Whole layer
|
11
|
11 (100.0%)
|
|
Lymph node metastasis
|
|
Yes
|
41
|
38 (92.7%)
|
0.036
|
|
No
|
19
|
13 (68.4%)
|
|
HPV
|
|
(+)
|
55
|
49 (89.1%)
|
0.022
|
|
(−)
|
5
|
2 (40.0%)
|
- aClC3(+) denotes overexpression of ClC3 protein
- bBy Pearson’s χ2 test or Fisher’s exact test
- cWDSCC, Highly differentiated squamous carcinoma; MDSCC, moderately differentiated squamous cell carcinoma; PDSCC, poorly differentiated squamous cell carcinoma
