Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis

Table 2 Cervical cancer patient characteristics and ClC-3 expression

Characteristic	Total (60)	No. of CIC-3(+) cases (%)^a	p^b
Age (years)
Mean (SD)	45.44 ± 11.3
Stage
I	22	15 (68.2%)	0.016
II	38	36 (94.7%)	0.016
Histological grades
HDSCC^c	19	13 (68.4%)	0.029
MDSCC^c	25	22 (88.0%)
PDSCC^c	16	16 (100.0%)
Tumor size (cm)
D ≤ 4	31	23 (74.2%)	0.039
D > 4	29	28 (96.6%)	0.039
Vascular invasion
Yes	21	21 (100.0%)	0.045
No	39	30 (76.9%)	0.045
Invasive interstitial depth
< 1/2	21	14 (66.7%)	0.012
≥ 1/2	28	26 (92.9%)
Whole layer	11	11 (100.0%)
Lymph node metastasis
Yes	41	38 (92.7%)	0.036
No	19	13 (68.4%)	0.036
HPV
(+)	55	49 (89.1%)	0.022
(−)	5	2 (40.0%)	0.022

^aClC3(+) denotes overexpression of ClC3 protein
^bBy Pearson’s χ² test or Fisher’s exact test
^cWDSCC, Highly differentiated squamous carcinoma; MDSCC, moderately differentiated squamous cell carcinoma; PDSCC, poorly differentiated squamous cell carcinoma

ISSN: 1475-2867