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Table 2 Cervical cancer patient characteristics and ClC-3 expression

From: Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis

Characteristic Total (60) No. of CIC-3(+) cases (%)a pb
Age (years)
 Mean (SD) 45.44 ± 11.3   
Stage
 I 22 15 (68.2%) 0.016
 II 38 36 (94.7%)
Histological grades
 HDSCCc 19 13 (68.4%) 0.029
 MDSCCc 25 22 (88.0%)
 PDSCCc 16 16 (100.0%)
Tumor size (cm)
 D ≤ 4 31 23 (74.2%) 0.039
 D > 4 29 28 (96.6%)
Vascular invasion
 Yes 21 21 (100.0%) 0.045
 No 39 30 (76.9%)
Invasive interstitial depth
 < 1/2 21 14 (66.7%) 0.012
 ≥ 1/2 28 26 (92.9%)
 Whole layer 11 11 (100.0%)
Lymph node metastasis
 Yes 41 38 (92.7%) 0.036
 No 19 13 (68.4%)
HPV
 (+) 55 49 (89.1%) 0.022
 (−) 5 2 (40.0%)
  1. aClC3(+) denotes overexpression of ClC3 protein
  2. bBy Pearson’s χ2 test or Fisher’s exact test
  3. cWDSCC, Highly differentiated squamous carcinoma; MDSCC, moderately differentiated squamous cell carcinoma; PDSCC, poorly differentiated squamous cell carcinoma