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Table 3 The associations of ESR1 and ESR2 polymorphisms with breast cancer risk (adjusted by age and BMI)

From: Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Model Genotype Cases (n, %) Control (n, %) OR (95% CI) P-value AIC BIC
rs2881766 459 549  
Codominant TT 173 (37.7%) 178 (32.4%) 1.00
  GT 218 (47.5%) 260 (47.4%) 0.87 (0.66–1.15)
  GG 68 (14.8%) 111 (20.2%) 0.63 (0.440.91) 0.046 1387.9 1412.5
Dominant TT 173 (37.7%) 178 (32.4%) 1.00
GT/GG 286 (62.3%) 371 (67.6%) 0.80 (0.62–1.04) 0.091 1389.2 1408.9
Recessive TT/GT 391 (85.2%) 438 (79.8%) 1.00
GG 68 (14.8%) 111 (20.2%) 0.68 (0.490.95) 0.022* 1386.9 1406.5
Overdominant TT/GG 241 (52.5%) 289 (52.6%) 1.00
GT 218 (47.5%) 260 (47.4%) 1.02 (0.79–1.30) 0.9 1392.1 1411.7
rs9383951 458 549  
Codominant GG 379 (82.8%) 442 (80.5%) 1.00
  GC 76 (16.6%) 102 (18.6%) 0.89 (0.64–1.23)
  CC 3 (0.7%) 5 (0.9%) 0.77 (0.18–3.28) 0.74 1391.7 1416.3
Dominant GG 379 (82.8%) 442 (80.5%) 1.00
GC/CC 79 (17.2%) 107 (19.5%) 0.88 (0.64–1.22) 0.45 1389.8 1409.4
Recessive GG/GC 455 (99.3%) 544 (99.1%) 1.00
CC 3 (0.7%) 5 (0.9%) 0.79 (0.19–3.35) 0.75 1390.3 1409.9
Overdominant GG/CC 382 (83.4%) 447 (81.4%) 1.00
GC 76 (16.6%) 102 (18.6%) 0.89 (0.64–1.24) 0.48 1389.9 1409.5
rs9340799 459 549  
Codominant AA 289 (63%) 349 (63.6%) 1.00
  GA 144 (31.4%) 179 (32.6%) 0.97 (0.74–1.27)
  GG 26 (5.7%) 21 (3.8%) 1.44 (0.79–2.62) 0.44 1392.5 1417.0
Dominant AA 289 (63%) 349 (63.6%) 1.00
GA/GG 170 (37%) 200 (36.4%) 1.02 (0.79–1.32) 0.89 1392.1 1411.7
Recessive AA/GA 433 (94.3%) 528 (96.2%) 1.00
GG 26 (5.7%) 21 (3.8%) 1.46 (0.81–2.63) 0.21 1390.5 1410.2
Overdominant AA/GG 315 (68.6%) 370 (67.4%) 1.00
GA 144 (31.4%) 179 (32.6%) 0.94 (0.72–1.23) 0.67 1391.9 1411.6
rs3020449 459 549  
Codominant TT 176 (38.3%) 267 (48.6%) 1.00
  CT 230 (50.1%) 224 (40.8%) 1.58 (1.212.06)
  CC 53 (11.6%) 58 (10.6%) 1.39 (0.91–2.11) 0.003 1382.5 1407.1
Dominant TT 176 (38.3%) 267 (48.6%) 1.00
CT/CC 283 (61.7%) 282 (51.4%) 1.54 (1.201.98) 8e−04* 1380.8 1400.5
Recessive TT/CT 406 (88.5%) 491 (89.4%) 1.00
CC 53 (11.6%) 58 (10.6%) 1.10 (0.74–1.64) 0.64 1391.9 1411.5
Overdominant TT/CC 229 (49.9%) 325 (59.2%) 1.00
CT 230 (50.1%) 224 (40.8%) 1.48 (1.151.90) 0.002 1382.8 1402.5
  1. The significant ORs and 95%CIs were presented in italic
  2. OR odds ratio, 95% CI confidence interval, AIC Akaike’s information criterion, BIC Bayesian information criterion
  3. P-value of best-fit model