Table 3 The associations of ESR1 and ESR2 polymorphisms with breast cancer risk (adjusted by age and BMI)
Model | Genotype | Cases (n, %) | Control (n, %) | OR (95% CI) | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|
rs2881766 | 459 | 549 | |||||
Codominant | TT | 173 (37.7%) | 178 (32.4%) | 1.00 | – | – | – |
GT | 218 (47.5%) | 260 (47.4%) | 0.87 (0.66–1.15) | – | – | – | |
GG | 68 (14.8%) | 111 (20.2%) | 0.63 (0.44–0.91) | 0.046 | 1387.9 | 1412.5 | |
Dominant | TT | 173 (37.7%) | 178 (32.4%) | 1.00 | – | – | – |
GT/GG | 286 (62.3%) | 371 (67.6%) | 0.80 (0.62–1.04) | 0.091 | 1389.2 | 1408.9 | |
Recessive | TT/GT | 391 (85.2%) | 438 (79.8%) | 1.00 | – | – | – |
GG | 68 (14.8%) | 111 (20.2%) | 0.68 (0.49–0.95) | 0.022* | 1386.9 | 1406.5 | |
Overdominant | TT/GG | 241 (52.5%) | 289 (52.6%) | 1.00 | – | – | – |
GT | 218 (47.5%) | 260 (47.4%) | 1.02 (0.79–1.30) | 0.9 | 1392.1 | 1411.7 | |
rs9383951 | 458 | 549 | |||||
Codominant | GG | 379 (82.8%) | 442 (80.5%) | 1.00 | – | – | – |
GC | 76 (16.6%) | 102 (18.6%) | 0.89 (0.64–1.23) | – | – | – | |
CC | 3 (0.7%) | 5 (0.9%) | 0.77 (0.18–3.28) | 0.74 | 1391.7 | 1416.3 | |
Dominant | GG | 379 (82.8%) | 442 (80.5%) | 1.00 | – | – | – |
GC/CC | 79 (17.2%) | 107 (19.5%) | 0.88 (0.64–1.22) | 0.45 | 1389.8 | 1409.4 | |
Recessive | GG/GC | 455 (99.3%) | 544 (99.1%) | 1.00 | – | – | – |
CC | 3 (0.7%) | 5 (0.9%) | 0.79 (0.19–3.35) | 0.75 | 1390.3 | 1409.9 | |
Overdominant | GG/CC | 382 (83.4%) | 447 (81.4%) | 1.00 | – | – | – |
GC | 76 (16.6%) | 102 (18.6%) | 0.89 (0.64–1.24) | 0.48 | 1389.9 | 1409.5 | |
rs9340799 | 459 | 549 | |||||
Codominant | AA | 289 (63%) | 349 (63.6%) | 1.00 | – | – | – |
GA | 144 (31.4%) | 179 (32.6%) | 0.97 (0.74–1.27) | – | – | – | |
GG | 26 (5.7%) | 21 (3.8%) | 1.44 (0.79–2.62) | 0.44 | 1392.5 | 1417.0 | |
Dominant | AA | 289 (63%) | 349 (63.6%) | 1.00 | – | – | – |
GA/GG | 170 (37%) | 200 (36.4%) | 1.02 (0.79–1.32) | 0.89 | 1392.1 | 1411.7 | |
Recessive | AA/GA | 433 (94.3%) | 528 (96.2%) | 1.00 | – | – | – |
GG | 26 (5.7%) | 21 (3.8%) | 1.46 (0.81–2.63) | 0.21 | 1390.5 | 1410.2 | |
Overdominant | AA/GG | 315 (68.6%) | 370 (67.4%) | 1.00 | – | – | – |
GA | 144 (31.4%) | 179 (32.6%) | 0.94 (0.72–1.23) | 0.67 | 1391.9 | 1411.6 | |
rs3020449 | 459 | 549 | |||||
Codominant | TT | 176 (38.3%) | 267 (48.6%) | 1.00 | – | – | – |
CT | 230 (50.1%) | 224 (40.8%) | 1.58 (1.21–2.06) | – | – | – | |
CC | 53 (11.6%) | 58 (10.6%) | 1.39 (0.91–2.11) | 0.003 | 1382.5 | 1407.1 | |
Dominant | TT | 176 (38.3%) | 267 (48.6%) | 1.00 | – | – | – |
CT/CC | 283 (61.7%) | 282 (51.4%) | 1.54 (1.20–1.98) | 8e−04* | 1380.8 | 1400.5 | |
Recessive | TT/CT | 406 (88.5%) | 491 (89.4%) | 1.00 | – | – | – |
CC | 53 (11.6%) | 58 (10.6%) | 1.10 (0.74–1.64) | 0.64 | 1391.9 | 1411.5 | |
Overdominant | TT/CC | 229 (49.9%) | 325 (59.2%) | 1.00 | – | – | – |
CT | 230 (50.1%) | 224 (40.8%) | 1.48 (1.15–1.90) | 0.002 | 1382.8 | 1402.5 | |