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Table 6 The associations between ESR2 rs3020449 and clinicopathological features of breast cancer

From: Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Variables Genotype OR (95% CI)
TT CT CC CC vs.TT CT vs.TT CT/CC vs.TT CC vs. TT/CT
Tumor size (cm)
< 2 69 66 17     
≥ 2 107 164 36 1.37 (0.71–2.62) 1.60 (1.06–2.43) 1.55 (1.05–2.31) 1.057 (0.57–1.95)
LN metastasis
No 74 90 20     
Yes 102 140 33 1.20 (0.64–2.25) 1.13 (0.76–1.68) 1.14 (0.78–1.67) 1.12 (0.62–2.02)
Histological grade
SBR 1–2 101 121 22     
SBR 3 75 109 31 1.90 (1.02–3.54) 1.21 (0.82–1.80) 1.32 (0.90–1.93) 1.70 (0.95–3.04)
Venous invasion
None-little 114 146 32     
Moderate-severe 62 84 21 1.21 (0.64–2.27) 1.06 (0.70–1.59) 1.08 (0.73–1.61) 1.17 (0.65–2.10)
ER
(−) 85 101 16     
(+) 91 129 37 2.16 (1.12–4.17) 1.19 (0.80–1.77) 1.33 (0.91–1.94) 1.96 (1.05–3.63)
PR
(−) 83 102 23     
(+) 93 128 30 1.16 (0.63–2.16) 1.12 (0.76–1.66) 1.13 (0.77–1.65) 1.09 (0.61–1.94)
Her-2
(−) 120 175 35     
(+) 56 55 18 1.10 (0.57–2.11) 0.67 (0.43–1.04) 0.74 (0.49–1.13) 1.37 (0.74–2.51)
Ki–67 (%)
< 14 112 153 29     
≥ 14 64 77 24 1.45 (0.78–2.70) 0.88 (0.58–1.33) 0.97 (0.66–1.44) 1.56 (0.87–2.77)
  1. The significant ORs and 95%CIs were presented in italic
  2. LN axillary lymph node, ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, SBR Scarff, Bloom and Richardson tumor grade, OR odds ratio; 95% CI confidence interval