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Table 6 The associations between ESR2 rs3020449 and clinicopathological features of breast cancer

From: Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Variables

Genotype

OR (95% CI)

TT

CT

CC

CC vs.TT

CT vs.TT

CT/CC vs.TT

CC vs. TT/CT

Tumor size (cm)

< 2

69

66

17

    

≥ 2

107

164

36

1.37 (0.71–2.62)

1.60 (1.06–2.43)

1.55 (1.05–2.31)

1.057 (0.57–1.95)

LN metastasis

No

74

90

20

    

Yes

102

140

33

1.20 (0.64–2.25)

1.13 (0.76–1.68)

1.14 (0.78–1.67)

1.12 (0.62–2.02)

Histological grade

SBR 1–2

101

121

22

    

SBR 3

75

109

31

1.90 (1.02–3.54)

1.21 (0.82–1.80)

1.32 (0.90–1.93)

1.70 (0.95–3.04)

Venous invasion

None-little

114

146

32

    

Moderate-severe

62

84

21

1.21 (0.64–2.27)

1.06 (0.70–1.59)

1.08 (0.73–1.61)

1.17 (0.65–2.10)

ER

(−)

85

101

16

    

(+)

91

129

37

2.16 (1.12–4.17)

1.19 (0.80–1.77)

1.33 (0.91–1.94)

1.96 (1.05–3.63)

PR

(−)

83

102

23

    

(+)

93

128

30

1.16 (0.63–2.16)

1.12 (0.76–1.66)

1.13 (0.77–1.65)

1.09 (0.61–1.94)

Her-2

(−)

120

175

35

    

(+)

56

55

18

1.10 (0.57–2.11)

0.67 (0.43–1.04)

0.74 (0.49–1.13)

1.37 (0.74–2.51)

Ki–67 (%)

< 14

112

153

29

    

≥ 14

64

77

24

1.45 (0.78–2.70)

0.88 (0.58–1.33)

0.97 (0.66–1.44)

1.56 (0.87–2.77)

  1. The significant ORs and 95%CIs were presented in italic
  2. LN axillary lymph node, ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, SBR Scarff, Bloom and Richardson tumor grade, OR odds ratio; 95% CI confidence interval
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Cancer Cell International

ISSN: 1475-2867

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