Expression of the Wnt ligands gene family and its relationship to prognosis in hepatocellular carcinoma

Table 3 Correlation of clinicopathologic variables and expression of several specific Wnts significantly associated with OS

Clinical features	Patients (n = 360)	Wnt 1		P value	Wnt 3		P value	Wnt 5B		P value	Wnt 6		P value	Wnt 8A		P value
Clinical features	Patients (n = 360)	Decreased	Increased	P value	Decreased	Increased	P value	Decreased	Increased	P value	Decreased	Increased	P value	Decreased	Increased	P value
Age (year)
< 60	165	81	84	0.87	67	98	0.54	24	141	0.46	136	29	0.49	159	6	0.20
≥ 60	195	94	101		73	122		34	161		166	29		192	3
Sex
Male	243	124	119	0.19	98	145	0.42	41	202	0.57	204	39	0.96	237	6	0.95
Female	117	51	66		42	75		17	100		98	19		114	3
Race
Asian	155	77	78	0.64	64	91	0.46	29	126	0.22	130	25	0.94	153	2	0.17
White + others	195	92	103		73	122		27	168		163	32		188	7
Missing	10
BMI
≤ 25	174	84	90	0.98	68	106	0.64	33	141	0.15	143	31	0.40	172	2	0.32
> 25	153	74	79		56	97		20	133		131	22		149	4
Missing	33
Grade
1–2	224	107	117	0.53	78	146	0.04	37	187	0.75	183	41	0.19	221	3	0.06
3–4	131	67	64		60	71		20	111		114	17		125	6
Missing	5
TNM stage
I–II	248	110	138	0.02	99	149	0.69	33	215	0.03	207	41	0.89	243	5	0.21
III–IV	88	52	36		33	55		20	68		74	14		84	4
Missing	24

OS overall survival, BMI body mass index, TNM stage tumor, node, metastasis stage
Italic values represent statistical significance

ISSN: 1475-2867