A DAAM1 3′-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis

Table 1 Associations between DAAM1 mRNA expression and clinicopathological characteristics in breast cancer

Characteristics	n	DAAM1^a		OR (95% Cl)	P value^b
Characteristics	n	Low	High	OR (95% Cl)	P value^b
Tumor size (cm)
≤ 2	61	35	26	1.82 (0.94–3.53)	0.075
> 2	87	50	50	1.82 (0.94–3.53)	0.075
Unknown	9
Lymph node metastasis
N0	121	73	48	9.43 (3.43–25.95)	< 0.001
N1–N3	36	5	31	9.43 (3.43–25.95)	< 0.001
Distant metastasis
M0	151	78	73	–	0.039
M1	6	0	6	–	0.039
ER status
Negative	51	23	28	0.76 (0.39–1.49)	0.426
Positive	106	55	51	0.76 (0.39–1.49)	0.426
PR status
Negative	67	31	37	0.77 (0.41–1.45)	0.419
Positive	89	47	42	0.77 (0.41–1.45)	0.419
Unknown	1
Her-2 status
Negative	94	45	49	0.89 (0.47–1.69)	0.720
Positive	61	31	30	0.89 (0.47–1.69)	0.720
Unknown	2
P53 status
Negative	105	51	54	0.99 (0.48–2.04)	0.982
Positive	41	20	21	0.99 (0.48–2.04)	0.982
Unknown	11
Ki67 status
Negative	33	19	14	1.53 (0.70–3.33)	0.285
Positive	119	56	63	1.53 (0.70–3.33)	0.285
Unknown	5

ISSN: 1475-2867