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Fig. 3 | Cancer Cell International

Fig. 3

From: Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma

Fig. 3

HNF4α knockdown decreases the gemcitabine resistance of pancreatic cancer cells. a downregulation of HNF4α decreased IC50 value of gemcitabine in Capan-1 and MiaPaCa-2 cells. b, c Apoptosis rates of the HNF4α-silenced cell lines with or without gemcitabine treatment. d Western blotting analysis of apoptosis-related proteins, cleaved PARP1 and cleaved Caspase-9, of the pancreatic cancer cell lines with or without gemcitabine treatment. *Represented significant differences (P < 0.05, compared with group control); **Represented with significant differences (P < 0.01, compared with group control)

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Cancer Cell International

ISSN: 1475-2867

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