Fig. 1
From: WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia
WP1130 inhibits proliferation and reduces viability of T-ALL cells. a Chemical structure of WP1130. b, c Jurkat, Molt-4, HPB and CCRF-CEM of different T-ALL cell lines were treated with indicated dose of WP1130 for 24 h. The inhibition of proliferation was determined by CCK-8 assays and cell viability was evaluated by trypan blue exclusion assay. d The treated or untreated T-ALL cell lines were stained with Hoechst 33342 and PI and then visualized by fluorescence microscope. e, f PBMCs from T-ALL patients or normal control were treated with WP1130 at indicated concentrations for 24 h and subjected to trypan blue exclusion assay to determine cell viability. All values represent mean ± SD of three independent experiments. *P < 0.05 vs. control group