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Table 2 Nucleotide sequence variations in E6 and E7 of HPV16 (n = 75)

From: Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China

  

E6 base sites

HPV16 variants:

T109C

A131C

C168G

G176A

T178G

T178A

T183G

A275G

A276G

T295G

AA changes:

T22S

D25N

D25E

D25Q

I27R

N58D

N58S

D64E

E reference:

T

A

C

G

T

T

T

A

A

T

AA:

T

A

C

G

T

T

T

A

A

T

As:

T

A

C

G

G

G

T

A

A

T

Af:

T

A

C

G

T

T

T

A

A

T

Mutation:

1/75

1/75

1/75

1/75

19/75

1/75

2/75

1/75

1/75

1/75

Ep

11

          

Ep

3

          

Ep

2

      

G

   

Ep

2

          

Ep

1

     

A

  

G

 

Ep

1

          

Ep

1

   

A

      

E-350G

30

          

E-350G

1

          

E-350G

1

c

         

E-350G

1

          

E-350G

1

         

G

E-350G

1

       

G

  

E-350G

1

  

G

 

G

     

As

15

    

G

     

As

2

    

G

     

As

1

 

c

  

G

     
  

E6 base sites

E7 base sites

 

HPV16 variants:

T350G

C360A

A442C

A645C

A646C

A647G

G666A

T760C

T846C

AA changes:

L83V

T86K

E113

L28F

N29H

N29S

   

E reference:

T

C

A

A

A

A

G

T

T

AA:

G

C

A

A

A

A

G

T

T

As:

T

C

A

A

A

G

G

T

C

Af:

T

C

A

A

A

A

G

T

T

Mutation:

36/75

1/75

1/75

1/75

1/75

18/75

4/75

4/75

3/75

Ep

11

          

Ep

3

       

c

  

Ep

2

          

Ep

2

      

a

   

Ep

1

      

a

   

Ep

1

      

a

   

Ep

1

       

c

  

E-350G

30

G

         

E-350G

1

G

 

C

C

      

E-350G

1

G

         

E-350G

1

G

         

E-350G

1

G

A

        

E-350G

1

G

         

E-350G

1

G

   

C

     

As

15

     

G

    

As

2

     

G

  

c

 

As

1

     

G

  

c

 
  1. Bolditalic are the most common mutation sites
  2. Capital letters indicate variants with an amino acid change, lower-case letters indicate silent mutations
  3. AA change amino acid change, Ep European prototype, AA Asian–American lineage, As Asian lineage, Af African lineage
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Cancer Cell International

ISSN: 1475-2867

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