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Table 2 Univariate of factors associated with overall survival (n = 160)

From: MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Variables

Hazard ratio

95% confidence interval

P value

Age (> 45 vs ≤ 45)

0.739

0.437–1.249

0.258

Gender (male vs female)

0.995

0.561–1.764

0.986

Tumor differentiation (III–IV vs I–II)

2.267

1.339–3.837

0.002*

Tumor size, cm (> 5 vs ≤ 5)

0.997

0.587–1.694

0.991

HBsAg (positive vs negative)

0.865

0.461–1.624

0.652

Liver cirrhosis (positive vs negative)

1.025

0.619–1.695

0.925

Tumor encapsulation (none vs complete)

1.155

0.704–1.893

0.568

Child–Pugh score (B vs A)

0.767

0.466–1.260

0.295

Microvascular invasion (positive vs negative)

1.852

1.019–3.368

0.043*

AFP, ng/ml (> 50 vs ≤ 50)

1.431

0.730–2.803

0.297

TNM stage (III–IV vs I–II)

0.549

0.319–0.945

0.030*

Tumor number (multiple vs single)

0.690

0.403–1.180

0.175

MKP-4 (low vs high)

0.145

0.069–0.304

< 0.001*

ERK1/2 (low vs high)

2.377

1.226–4.610

0.010*

p-ERK1/2 (low vs high)

2.874

1.500–5.507

0.001*

  1. Statistical analyses were performed using log-rank test
  2. * P < 0.05 was considered significant
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Cancer Cell International

ISSN: 1475-2867

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