Fig. 6

miR-199a-5p-inhibition abrogated SNHG12-silencing elicited tumor suppressive effect. a The relative miR-199a-5p level in response to SNHG12 knockdown or specific inhibitor was determined by real-time PCR in both Caki-1 and ACHN cells. ****p < 0.0001. b The suppressive effect on cell viability of SNHG12 deficiency was relieved by miR-199a-5p inhibition. The cell viability was monitor at 0, 24, 48 and 72 h respectively using CCK-8 kit. ns, no significance, *p < 0.05, ***p < 0.001, ****p < 0.0001. c Colony formation assay was performed to measure the anchorage-independent growth of indicated cells. ns, no significance, ****p < 0.0001. d The invasive capacity was determined by Matrigel-coated Transwell assay. ns, no significance, ****p < 0.0001