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Fig. 4 | Cancer Cell International

Fig. 4

From: Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

Fig. 4

Lycopene reduces the methylation levels of IRF1 and IRF7 promoters to promote IFNγ expression. The IFN-related gene expressions were measured by qRT-PCR (a–d). After the treatment of lycopene and/or PD-1 therapy, the methylation status of IRF1/7 promoter regions were assessed by bisulfite sequencing analysis, (black circle, methylated cytosine of CpG; white circle, unmethylated cytosine of CpG) (e). The expression levels of DNMT1, DNMT3A, and DNMT3B in the tumor tissues were analyzed by Western blot (f, g). *p < 0.05 vs. control, #p < 0.05 vs. Anti-PD-1 (n = 6)

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Cancer Cell International

ISSN: 1475-2867

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