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Table 2 Univariate analysis and multivariate analysis for predictors of overall survival

From: RETRACTED ARTICLE: TMED3 promotes cell proliferation and motility in breast cancer and is negatively modulated by miR-188-3p

Variables

Univariate analysis

Multivariate analysis

HR

CI

p

HR

CI

p

Age

1.782

1.077–2.947

0.024

1.637

0.769–3.483

0.303

Tumor size

0.389

0.177–0.855

0.019

1.404

0.762–2.587

0.245

N classification

0.160

0.079–0.324

0.000*

0.192

0.092–0.400

0.000*

Grading

0.554

0.287–1.271

0.184

0.757

0.347–1.652

0.484

ER status

0.413

0.187–0.540

0.000*

0.345

0.155–0.768

0.496

PR status

0.457

0.270–0.737

0.002

1.302

0.609–2.783

0.006

HER-2 status

1.013

0.615–1.287

0.018

1.914

1.253–3.724

0.021

Staging

1.422

1.379–3.185

0.068

1.687

0.914–2.849

0.083

TMED3

3.059

1.763–5.309

0.000*

1.852

1.013–3.387

0.017

  1. Variables: age, > 48 vs. ≤ 48; tumor size, < 2 cm vs. ≥ 2 cm, LNM, negative vs. positive, Chemotherapy, yes vs. no; ER status, positive vs. negative; PR status, positive vs. negative; HER-2 status, positive vs. negative; Ki-67 status, positive vs. negative; TMED3, high expression vs. low expression; Cox proportional hazards model; “*” represent “p < 0.001”
  2. HR hazard ratio, CI confidence interval, TMED3 transmembrane P24 trafficking protein 3, ER estrogen receptor, PR progesterone receptor, HER-2 human epidermal growth factor receptor-2, Ki-67 protein encoded by the MKI67 gene
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Cancer Cell International

ISSN: 1475-2867

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