Table 2 Main results of the meta-analysis on the association between GSTM1 and GSTT1 null polymorphisms and HCC risk
Null genotype | No. of studies | OR (95% CI) | P(Q) | I2 (%) | P(H) |
|---|---|---|---|---|---|
GSTM1 | 46 | 1.37 (1.18–1.59) | < 0.001 | 77.2 | < 0.001 |
Subgroup analysis | |||||
 Ethnicity | |||||
  Asian | 39 | 1.44 (1.22–1.71) | < 0.001 | 78.2 | < 0.001 |
  African | 3 | 1.31 (0.98–1.76) | 0.398 | 0 | 0.073 |
  Caucasian | 4 | 0.93 (0.77–1.13) | 0.312 | 16.0 | 0.476 |
 Type of control | |||||
  Healthy | 33 | 1.37 (1.17–1.59) | < 0.001 | 68.0 | < 0.001 |
  CLD | 13 | 1.36 (0.94–1.95) | < 0.001 | 87.3 | 0.099 |
  GSTT1 | 34 | 1.43 (1.23–1.66) | < 0.001 | 69.3 | < 0.001 |
Subgroup analysis | |||||
 Ethnicity | |||||
  Asian | 28 | 1.48 (1.25–1.77) | < 0.001 | 71.9 | < 0.001 |
  African | 3 | 1.21 (0.77–1.90) | 0.122 | 52.4 | 0.404 |
  Caucasian | 3 | 1.19 (0.93–1.51) | 0.273 | 23.0 | 0.164 |
 Type of control | |||||
  Healthy | 24 | 1.42 (1.21–1.66) | < 0.001 | 58.2 | < 0.001 |
  CLD | 10 | 1.45 (1.02–2.08) | < 0.001 | 82.8 | 0.041 |
  GSTM1–GSTT1 | 19 | 1.58 (1.22–2.05) | < 0.001 | 46.1 | 0.001 |
Subgroup analysis | |||||
 Ethnicity | |||||
  Asian | 17 | 1.58 (1.19–2.09) | < 0.001 | 64.1 | 0.002 |
  African | 1 | – | – | – | – |
  Caucasian | 1 | – | – | – | – |
 Type of control | |||||
  Healthy | 14 | 1.61 (1.17–2.22) | < 0.001 | 64.7 | 0.003 |
  CLD | 5 | 1.20 (0.94–1.53) | 0.179 | 36.3 | 0.153 |