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Fig. 1 | Cancer Cell International

Fig. 1

From: PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway

Fig. 1

PITX2 was highly expressed in lung adenocarcinoma and correlated with clinicopathological characteristics. a Utilizing the TCGA dataset, we found that PITX2 was overexpressed in lung adenocarcinoma compared with adjacent normal tissues (Normal 0.3692 ± 0.07735 N = 58; Tumor 4.863 ± 0.1323 N = 511. p < 0.001). b Patients with higher PITX2 expression had a relatively lower overall survival. (p = 0.0345). c PITX2 was upregulated in 76.67% of lung adenocarcinoma tissues collected from our own hospital (normalized to adjacent normal tissues). d–f Overexpression of PITX2 correlated with advanced T stage, N stage and TNM stage. g, h PITX2 mRNA and protein are highly expressed in LUAD cell lines (normalized to HBE, human bronchial epithelial cell) (*p < 0.05, **p < 0.01, ***p < 0.001)

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Cancer Cell International

ISSN: 1475-2867

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