Fig. 4

SBCCC induces cell apoptosis via inhibition of NF-κB signaling and ROS production. a Western blot analysis for protein levels of Bcl-2, Bax, caspase-3, cleaved caspase-3, cleaved PARP-1, and cytochrome C (Cyto-c). h: hour; *P < 0.05. b Western blot analysis for protein levels of p-IκB, IκB and NF-κB. h: hour; *P < 0.05. c Cell colony formation assay. h: hour; *P < 0.05 vs control; ^#P < 0.05 vs PDTC. d Left, ROS production detected by DCFH-DA staining. Right, Western blot analysis for protein levels of iNOS, JNK, and p-JNK. h: hour