Table 1 Effect of DA-9401 on body, reproductive organ weight, serum hormone concentration, sperm count, motility, and fertility parameters in adriamycin treated male SD rats

Body and organ weight

 Body weight (beginning; gm)

229.00 ± 3.97

225.10 ± 3.41

235.91 ± 3.66

239.22 ± 5.37

232.00 ± 2.10

 Body weight (sacrifice; gm)

413.40 ± 9.12

409.20 ± 9.15

320.80 ± 7.94*^#

369.88 ± 13.61*^#+

341.50 ± 7.98*

 Testis weight (gm)

2.03 ± 0.05

2.06 ± 0.02

0.81 ± 0.05*^#

0.91 ± 0.03*^#

1.14 ± 0.12*⁺

 Epididymis weight (gm)

0.72 ± 0.14

0.71 ± 0.01

0.48 ± 0.02*^#

0.59 ± 0.02*^#+

0.56 ± 0.03*⁺

 Seminal vesicles weight (gm)

1.34 ± 0.04

1.45 ± 0.05

0.66 ± 0.06*^#

1.03 ± 0.08*^#+

0.94 ± 0.07*⁺

 Prostate weight (gm)

0.97 ± 0.05

1.16 ± 0.07

0.67 ± 0.05*^#

0.90 ± 0.04^#+

0.66 ± 0.04*^$

 Penis weight (gm)

0.31 ± 0.01

0.31 ± 0.01

0.26 ± 0.01*^#

0.30 ± 0.01⁺

0.28 ± 0.01

Serum hormone levels

 Serum testosterone (ng/ml)

5.36 ± 0.96

5.53 ± 0.58

0.42 ± 0.07*^#

1.62 ± 0.13*^#

2.75 ± 0.51*⁺

 Serum LH (mIU/ml)

39.10 ± 4.07

46.17 ± 2.41

101.26 ± 8.67*^#

84.33 ± 11.60*^#

88.27 ± 10.62*

 Serum FSH (ng/ml)

4.07 ± 0.58

4.57 ± 0.88

14.30 ± 1.68*^#

4.41 ± 1.85⁺

4.41 ± 0.23⁺

Sperm count and motility

 Sperm count (10⁶/ml)

  Vas deference

29.14 ± 0.99

26.64 ± 1.82

17.35 ± 0.89*^#

22.42 ± 0.79*^#+

22.28 ± 0.28*⁺

  Epididymis

37.78 ± 1.28

34.78 ± 0.79

10.42 ± 2.01*^#

16.85 ± 0.96*^#+

18.28 ± 1.64*⁺

 Sperm motility (%)

  Vas deference

65.72 ± 3.06

60.60 ± 4.67

31.50 ± 2.12*^#

48.13 ± 2.72*⁺

39.99 ± 1.85*

  Epididymis

36.78 ± 1.45

38.92 ± 2.19

15.33 ± 1.71*^#

26.55 ± 1.65*^#+

22.57 ± 1.50*⁺

Fertility parameters

 Fertility rate (%)

100

100

50*^#

80

100⁺

 Pups per female

12.80 ± 0.78

11.90 ± 0.56

5.60 ± 1.96*^#

9.3 ± 1.78

10.50 ± 0.85⁺