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Fig. 2 | Cancer Cell International

Fig. 2

From: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Fig. 2

LATS2 overexpression augments 5-FU-mediated cell proliferation arrest and mobilization inhibition. a, b EdU staining was used to evaluate cell proliferation. The number of EdU positive cell was recorded. ce Proteins were isolated from SW480 cells and then western blotting was used to evaluate the expression of cyclin D1 and CDK4. f, g Transwell assay was used to observe the number of migrated cells. h, i RNA was isolated from SW480 cells and then the expression of metastatic genes were evaluated via qPCR. *p < 0.05 vs. control (ctrl) group; #p < 0.05 vs. 5-FU + ad-ctrl group; ad-ctrl: control null adenovirus vectors; ad-LATS2: LATS2 adenovirus vectors

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