Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women

Table 4 The association between rs11064, rs1045241 and rs1045242 and clinicopathological characteristics of endometrial cancer

Characteristics	rs11064				P ^a	rs1045241				P ^a	rs1045242				P ^a
Characteristics	AA	AG	GG	AG + GG	P ^a	CC	CT	TT	CC + CT	P ^a	AA	AG	GG	AG + GG	P ^a
FIGO stage					0.011					0.174					0.103
I	108	60	10	70	0.425	115	54	9	63	0.075	114	58	6	64	0.041
II	23	6	3	9		22	8	2	10		24	7	1	8
III–IV	7	4	5	9		6	9	1	10		6	9	1	10
Histologic grade					0.718					0.678					0.658
G1	56	29	5	34	0.966	57	28	5	33	0.554	56	30	4	34	0.383
G2	60	29	11	40		66	28	6	34		68	29	3	32
G3	22	12	2	14		20	15	1	16		20	15	1	16
Histological type					0.445					0.469					0.464
EC	112	57	17	74	1.000	114	61	11	72	0.182	116	62	8	70
Non-EC	26	13	1	14		29	10	1	11		28	12	0	12
Depth of MI					0.047					0.153					0.088
< 50%	95	53	17	70	0.077	98	98	8	65	0.114	97	60	6	66	0.034
≥ 50%	43	17	1	18		45	45	4	18		47	14	2	16
LVSI					0.708					0.338					0.562
No	118	63	16	79	0.350	122	122	10	75	0.274	123	67	7	74	0.297
Yes	20	7	2	9		21	21	2	8		21	7	1	8
LN metastasis					0.048					0.702					0.934
No	122	62	12	74	0.351	123	123	10	73	0.679	124	65	7	72	0.718
Yes	16	8	6	14		20	20	2	10		20	9	1	10
CA-125 level					0.261					0.296					0.115
≤ 35 U/mL	102	59	14	73	0.113	108	108	8	67	0.283	106	63	6	69	0.063
> 35 U/Ml	36	11	4	15		35	35	4	16		38	11	2	13
P53					0.198					0.092					0.141
Negative	75	34	13	47	0.890	83	31	8	39	0.108	84	33	5	38	0.082
Positive	63	36	5	41		60	40	4	44		60	41	3	44
ER					0.631					0.516					0.706
Negative	33	16	6	22	0.853	36	18	1	19	0.630	34	20	1	21	0.736
Positive	105	54	12	66		107	53	11	66		110	54	7	61
PR					0.604					0.860					0.439
Negative	49	20	6	26	0.353	49	23	3	26	0.651	49	22	4	26	0.722
Positive	89	50	12	62		94	48	9	57		95	52	4	56
Ki67					0.47					0.117					0.704
Negative	34	14	6	20	0.743	33	20	1	21	0.854	32	20	2	22	0.435
Positive	104	56	12	68		110	51	11	66		112	54	6	60

FIGO International Federation of Gynecology and Obstetrics, G1 well, G2 moderate, G3 poor, EC endometrial cancer, MI myometrial invasion, LVSI lymphovascular space involvement, LN lymph node
^aTwo-sided Chi-squared test or Fisher’s test

ISSN: 1475-2867