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Table 1 The correlation of CHIP and TRAF2 expression with the clinical characteristics of GC patients

From: The ubiquitin ligase CHIP modulates cellular behaviors of gastric cancer cells by regulating TRAF2

Characteristics Nr. of patients n = 100 CHIP expression TRAF2 expression
Low n = 66 (66%) High n = 34 (34%) p value Low n = 47 (47%) High n = 53 53%) p value
Age (years)     0.158    0.106
 Median 65 (32–81)       
 ≤ 65 51 37 (72.5) 14 (27.5)   28 (54.9) 23 (45. 1)  
 > 65 49 29 (59.2) 20 (40.8)   19 (38.8) 30 (61.2)  
Gender     0.225    0.102
 Male 64 45 (70.3) 19 (29.7)   34 (53.1) 30 (46.9)  
 Female 36 21 (58.3) 15 (41.7)   13 (36.1) 23 (63.9)  
Tumor diameter (cm)     0.327    0.067
 ≤ 5  52 32 (61.5) 20 (38.5)   29 (55.8) 23 (44.2)  
 > 5  48 34 (70.8) 14 (29.2)   18 (37.5) 30 (62.5)  
Site of tumor     0.341    0.064
 Cardia 13 6 (46.2) 7 (53.8)   4 (30.8) 9 (69.2)  
 Body 28 21 (75) 7 (25)   16 (57.1) 12 (42.9)  
 Antrum 51 34 (66.7) 17 (33.3)   26 (51.0) 25 (49.0)  
 Unknown 8 5 (62.5) 3 (37.5)   1 (12.5) 7 (87.5)  
Histological types     0.541    0.004**
 Tubular adenocarcinoma 66 41 (62.1) 25 (37.9)   26 (39.4) 40 (60.6)  
 Mucinous adenocarcinoma 10 8 (80.0) 2 (20.0)   8 (80.0) 2 (20.0)  
 Signet ring cell adenocarcinoma 11 7 (63.6) 4 (36.4)   9 (81.8) 2 (18.2)  
 Undifferentiated carcinoma 13 10 (76.9) 3 (23.1)   4 (30.8) 9 (69.2)  
Tumor differentiation     0.133    0.017*
 Well 15 8 (53.3) 7 (46.7)   10 (66.7) 5 (33.3)  
 Moderate 74 49 (66.2) 25 (33.8)   35 (47.3) 39 (52.7)  
 Poor 11 9 (81.8) 2 (18.2)   2 (18.2) 9 (81.8)  
T classification     0.000***    0.005**
 T1–T2 15 4 (26.7) 11 (73.3)   12 (80.0) 3 (20.0)  
 T3–T4 85 62 (72.9) 23 (27.1)   35 (41.2) 50 (58.8)  
N classification     0.004**    0.000***
 N0–N1 42 21 (50.0) 21 (50.0)   30 (71.4) 12 (28.6)  
 N2–N3 58 45 (77.6) 13 (22.4)   17 (29.3) 41 (70.7)  
M classification     0.250    0.056
 M0 91 58 (63.7) 33 (36.3)   46 (50.5) 45 (49.5)  
 M1 9 8 (88.9) 1 (11.1)   1 (11.1) 8 (88.9)  
TNM stage     0.001***    0.000***
 I–II 42 20 (47.6) 22 (52.4)   32 (76.2) 10 (23.8)  
 III–IV 58 46 (79.3) 12 (20.7)   15 (25.9) 43 (74.1)  
  1. p < 0.05, ** p < 0.01, *** p < 0.001