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Fig. 1 | Cancer Cell International

Fig. 1

From: Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Fig. 1

Transcript levels of MacroH2A1 and splicing regulators in prostate tissue samples. a Transcriptional status of total MacroH2A1, MacroH2A1.1 and MacroH2A1.2 isoforms in MNPT samples (n = 15), PIN lesions (n = 45) and PCa samples (n = 197), assessed by RT-qPCR, and normalized with GUSB gene. b Transcript levels of three splicing regulators of H2AFY mRNA—QKI, DDX5 and DDX17—assessed by RT-qPCR, and normalized with GUSB gene. MNPT morphologically normal prostate tissue, PIN prostatic intraepithelial neoplasia, PCa prostate carcinoma, KW Kruskal–Wallis test. Inter-group analysis with Kruskal–Wallis test, followed by Dunn’s multiple comparisons test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns not significant

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