Fig. 2

Increased UBN2 expression is associated with CRC progression and poor prognosis. a Representative images of UBN2 expression in normal intestinal epithelium and CRC specimens (n = 20) examined by IHC. Scale bars: 50 µm. Histograms represent the statistics of UBN2 expression. b The expression of UBN2 in primary CRC and liver metastasis analyzed using Oncomine database (Tsuji colorectal, p < 0.01). c Representative images of UBN2 expression in liver metastasis by IHC (n = 3). Scale bars, 50 µm. d Effect of UBN2′s expression level on overall survival and disease-free survival by using Kaplan–Meier analyses