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Table 3 Candidate drugs targeting hub genes

From: Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy

Number Gene Drug Interaction types Approved? Scoresa Ref. (PubMed ID)
1 CDK1 ELTROMBOPAG Agonist FDA 1
2 CDK1 ROMIPLOSTIM Agonist FDA 1
3 TOP2A DOXORUBICIN HYDROCHLORIDE Inhibitor FDA 13
4 TOP2A TENIPOSIDE Inhibitor FDA 12 8702194; 16271071; 17361331; 17514873; 11752352; 16480143; 9426516
5 TOP2A ETOPOSIDE Inhibitor FDA 12 8823806; 9485461; 8870683; 9494516; 9426516
6 TOP2A VINCRISTINE FDA 10 9494516
7 TOP2A DOXORUBICIN Inhibitor FDA 9
8 TOP2A NORFLOXACIN Inhibitor FDA 6 11752352
9 TOP2A VALRUBICIN Inhibitor FDA 6 11752352; 16019763
10 TOP2A LEVOFLOXACIN Inhibitor FDA 4 11752352
11 TOP2A ENOXACIN Inhibitor FDA 4 18471102; 11752352; 10089819
12 TOP2A ETOPOSIDE PHOSPHATE FDA 3
13 TOP2A PACLITAXEL FDA 2
14 TOP2A DAUNORUBICIN Inhibitor FDA 2 9494516
15 TOP2A OFLOXACIN Inhibitor FDA 2 2847647
16 TOP2A IDARUBICIN HYDROCHLORIDE Inhibitor FDA 2
17 TOP2A PEFLOXACIN Inhibitor FDA 2 11752352
18 TOP2A DAUNORUBICIN HYDROCHLORIDE Inhibitor FDA 2
19 TOP2A MITOXANTRONE DIHYDROCHLORIDE Inhibitor FDA 2
20 TOP2A AMSACRINE Inhibitor FDA 2 1322791; 8823806; 10691026; 8519659; 8632768; 11006484; 11716434; 11752352; 11473732; 1311390
21 TOP2A PODOFILOX Inhibitor FDA 2 16061385; 1334447; 10783066; 11752352; 1845848; 1331331
22 TOP2A DEXRAZOXANE FDA 2 12911317
23 TOP2A MITOXANTRONE Inhibitor FDA 2 10451375; 11004693; 18687447; 11752352; 9631585; 9494516; 11278845; 9426516
24 TOP2A LOMEFLOXACIN Inhibitor FDA 1 11752352
25 TOP2A EPIRUBICIN Inhibitor FDA 1 14728934; 16234514; 17639997
26 TOP2A DACTINOMYCIN FDA 1 9494516
27 TOP2A DAUNORUBICIN CITRATE Inhibitor FDA 1
28 TOP2A FINAFLOXACIN Inhibitor FDA 1 25808831
29 TOP2A IDARUBICIN FDA 1
30 TOP2A HYDROQUINONE FDA 1 15833037
31 CCNA2 ETHINYL ESTRADIOL FDA 2 9806355
32 AURKB SUNITINIB Inhibitor FDA 1
33 AURKB SUNITINIB MALATE Inhibitor FDA 1
  1. aThe score is the combined number of database sources and PubMed references supporting a given interaction