Table 3 Candidate drugs targeting hub genes
Number | Gene | Drug | Interaction types | Approved? | Scoresa | Ref. (PubMed ID) |
|---|---|---|---|---|---|---|
1 | CDK1 | ELTROMBOPAG | Agonist | FDA | 1 | – |
2 | CDK1 | ROMIPLOSTIM | Agonist | FDA | 1 | – |
3 | TOP2A | DOXORUBICIN HYDROCHLORIDE | Inhibitor | FDA | 13 | – |
4 | TOP2A | TENIPOSIDE | Inhibitor | FDA | 12 | 8702194; 16271071; 17361331; 17514873; 11752352; 16480143; 9426516 |
5 | TOP2A | ETOPOSIDE | Inhibitor | FDA | 12 | 8823806; 9485461; 8870683; 9494516; 9426516 |
6 | TOP2A | VINCRISTINE | – | FDA | 10 | 9494516 |
7 | TOP2A | DOXORUBICIN | Inhibitor | FDA | 9 | – |
8 | TOP2A | NORFLOXACIN | Inhibitor | FDA | 6 | 11752352 |
9 | TOP2A | VALRUBICIN | Inhibitor | FDA | 6 | 11752352; 16019763 |
10 | TOP2A | LEVOFLOXACIN | Inhibitor | FDA | 4 | 11752352 |
11 | TOP2A | ENOXACIN | Inhibitor | FDA | 4 | 18471102; 11752352; 10089819 |
12 | TOP2A | ETOPOSIDE PHOSPHATE | – | FDA | 3 | – |
13 | TOP2A | PACLITAXEL | – | FDA | 2 | – |
14 | TOP2A | DAUNORUBICIN | Inhibitor | FDA | 2 | 9494516 |
15 | TOP2A | OFLOXACIN | Inhibitor | FDA | 2 | 2847647 |
16 | TOP2A | IDARUBICIN HYDROCHLORIDE | Inhibitor | FDA | 2 | – |
17 | TOP2A | PEFLOXACIN | Inhibitor | FDA | 2 | 11752352 |
18 | TOP2A | DAUNORUBICIN HYDROCHLORIDE | Inhibitor | FDA | 2 | – |
19 | TOP2A | MITOXANTRONE DIHYDROCHLORIDE | Inhibitor | FDA | 2 | – |
20 | TOP2A | AMSACRINE | Inhibitor | FDA | 2 | 1322791; 8823806; 10691026; 8519659; 8632768; 11006484; 11716434; 11752352; 11473732; 1311390 |
21 | TOP2A | PODOFILOX | Inhibitor | FDA | 2 | 16061385; 1334447; 10783066; 11752352; 1845848; 1331331 |
22 | TOP2A | DEXRAZOXANE | – | FDA | 2 | 12911317 |
23 | TOP2A | MITOXANTRONE | Inhibitor | FDA | 2 | 10451375; 11004693; 18687447; 11752352; 9631585; 9494516; 11278845; 9426516 |
24 | TOP2A | LOMEFLOXACIN | Inhibitor | FDA | 1 | 11752352 |
25 | TOP2A | EPIRUBICIN | Inhibitor | FDA | 1 | 14728934; 16234514; 17639997 |
26 | TOP2A | DACTINOMYCIN | – | FDA | 1 | 9494516 |
27 | TOP2A | DAUNORUBICIN CITRATE | Inhibitor | FDA | 1 | – |
28 | TOP2A | FINAFLOXACIN | Inhibitor | FDA | 1 | 25808831 |
29 | TOP2A | IDARUBICIN | – | FDA | 1 | – |
30 | TOP2A | HYDROQUINONE | – | FDA | 1 | 15833037 |
31 | CCNA2 | ETHINYL ESTRADIOL | – | FDA | 2 | 9806355 |
32 | AURKB | SUNITINIB | Inhibitor | FDA | 1 | – |
33 | AURKB | SUNITINIB MALATE | Inhibitor | FDA | 1 | – |