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Table 2 Main characteristics of included studies about PD-1 in this meta-analysis

From: The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Author Year Origin Range of year Categories No. of patients Cut off value for PD-1 positive No. of positive Detected area Endpoints Detection method Hazard ratio Calculation of HRs Quality score
Cao et al. 2018 China NA Primary 108 H-score > 0 41 TIL OS FFPE, IHC Report Multivariate 7
Hsu et al. 2010 China 2003–2004 Primary 46 > Median expression rate: 27.8% (intratumoral CD8), > median expression rate: 14.5% (intratumoral CD4) 23, 23 Intratumoral CD8, intratumoral CD4 OS FFPE, IHC Report Multivariate 7
Lu et al. 2018 China 2007–2012 Primary 197 PD-1 staining intensity 2 in > 5% of TILs 96 TIL OS FFPE, IHC K–M curve Univariate 7
Tang et al. 2017 China NA NA 96 NA 36 TIL OS FFPE, IHC K–M curve Univariate 6
Zhou et al. 2017 China 2001–2013 Recurrence 132 NA 50 TIL OS FFPE, IHC Report Univariate 9
Zhou et al. [2] 2017 China 2010–2012 Primary 99 PD-1 staining intensity 2 in > 5% of TILs 44 TIL OS FFPE, IHC K–M curve Univariate 9
  1. FFPE: Formalin-Fixed and Paraffin-Embedded; HRs: hazard ratios; IHC: immunohistochemistry; K–M curve: Kaplan–Meier curve; NA: not available; No: number; OS: overall survival; TIL: tumor infiltrating lymphocytes