Table 2 Main characteristics of included studies about PD-1 in this meta-analysis
Author | Year | Origin | Range of year | Categories | No. of patients | Cut off value for PD-1 positive | No. of positive | Detected area | Endpoints | Detection method | Hazard ratio | Calculation of HRs | Quality score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cao et al. | 2018 | China | NA | Primary | 108 | H-score > 0 | 41 | TIL | OS | FFPE, IHC | Report | Multivariate | 7 |
Hsu et al. | 2010 | China | 2003–2004 | Primary | 46 | > Median expression rate: 27.8% (intratumoral CD8), > median expression rate: 14.5% (intratumoral CD4) | 23, 23 | Intratumoral CD8, intratumoral CD4 | OS | FFPE, IHC | Report | Multivariate | 7 |
Lu et al. | 2018 | China | 2007–2012 | Primary | 197 | PD-1 staining intensity 2 in > 5% of TILs | 96 | TIL | OS | FFPE, IHC | K–M curve | Univariate | 7 |
Tang et al. | 2017 | China | NA | NA | 96 | NA | 36 | TIL | OS | FFPE, IHC | K–M curve | Univariate | 6 |
Zhou et al. | 2017 | China | 2001–2013 | Recurrence | 132 | NA | 50 | TIL | OS | FFPE, IHC | Report | Univariate | 9 |
Zhou et al. [2] | 2017 | China | 2010–2012 | Primary | 99 | PD-1 staining intensity 2 in > 5% of TILs | 44 | TIL | OS | FFPE, IHC | K–M curve | Univariate | 9 |