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Fig. 3 | Cancer Cell International

Fig. 3

From: Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Fig. 3

Comparison of the TGF-β-induced EMT model and the JAG2-overexpressing cell model. a Western blot analysis of the expression of EMT-related markers in HT29 cells after TGF-β induction and JAG2 overexpression. b Relative cell migration or invasion abilities were determined in HT29 cells treated with TGF-β (5 ng/mL), LY2157299 (100 nm) or Slug siRNA (20 nm) for 24 h. LY2157299 and Slug siRNA could inhibit TGF-β induced migration and invasion of colorectal cells. c Relative cell migration or invasion abilities were determined in JAG2-overexpressed HT29 cells treated with LY2157299 or Slug siRNA. LY2157299 and Slug siRNA could not inhibit JAG2-induced cell migration and invasion. Data are the mean ± SD. of three independent experiments. *P < 0.05 versus control

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Cancer Cell International

ISSN: 1475-2867

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