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Fig. 2 | Cancer Cell International

Fig. 2

From: Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Fig. 2

The Muv phenotype caused by LET-60 Ras overactivation is suppressed by the farnesylation inhibitor tipifarnib. a Structure of tipifarnib. b The Muv phenotype in let-60(n1046gf) is suppressed dose-dependently by tipifarnib treatment. d In kuIs12, 80 μM tipifarnib could suppress the Muv phenotype significantly as well. Statistical analysis of the Muv ratio and the number of ectopic vulvas are shown in c and e, respectively. White arrows indicate pseudovulvas and black arrowheads indicate normal vulvas. *p < 0.05; **p < 0.01; ***p < 0.001 by unpaired Student’s t-test

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Cancer Cell International

ISSN: 1475-2867

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