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Table 5 Univariate and multivariate analyses of prognostic factors

From: Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

Parameters

Patients

5-year OS rate (%)

Univariate analysis

Multivariate analysis

N (%)

P

HR

95% CI

P

Age (years)

  

0.560

   

 ≤ 60

53 (44.9)

52.8

    

 > 60

65 (55.1)

52.3

    

Sex

  

0.132

   

 Female

49 (41.5)

53.1

    

 Male

69 (58.5)

52.2

    

Tumor site

  

0.102

   

 Colon

66 (55.9)

53.0

    

 Rectum

52 (44.1)

51.9

    

Tumor size (cm)

  

0.032

1.752

0.892–2.321

0.087

 ≤ 4

63 (53.4)

57.1

    

 > 4

55 (46.6)

47.3

    

T stage

  

< 0.001

2.337

1.273–3.755

0.001

 T1

22 (18.6)

77.3

    

 T2

32 (27.1)

59.4

    

 T3

34 (28.8)

47.1

    

 T4

30 (25.4)

33.3

    

N stage

  

< 0.001

1.988

1.034–2.433

< 0.001

 N0

48 (40.7)

68.8

    

 N1

39 (33.1)

48.7

    

 N2

31 (26.3)

32.3

    

Differentiation degree

  

0.002

1.786

1.296–2.280

0.035

 Well

56 (47.5)

66.1

    

 Moderate

50 (42.4)

42.0

    

 Poor

12 (10.2)

33.3

    

Retrieved LN

  

0.182

   

 ≤ 12

61 (51.7)

52.5

    

 > 12

57 (48.3)

52.6

    

TNM stage

  

< 0.001

2.271

1.360–3.365

< 0.001

 I + II

48 (40.7)

68.8

    

 III

70 (59.3)

41.4

    

s-IQGAP3 (pg/ml)

  

0.007

1.915

1.441–2.673

0.012

 ≤ 186

14 (11.9)

85.7

    

 > 186

104 (88.1)

48.1

    

s-B7-H4 (ng/ml)

  

0.015

2.013

1.587–3.014

0.038

 ≤ 81

14 (11.9)

78.6

    

 > 81

104 (88.1)

49.0

    

s-COX-2 (ng/ml)

  

< 0.001

1.810

1.299–2.836

< 0.001

 ≤ 38

42 (35.6)

73.8

    

 > 38

76 (64.4)

40.8

    

t-IQGAP3

  

< 0.001

2.520

1.298–3.442

< 0.001

 Low

61 (51.7)

65.6

    

 High

57 (48.3)

38.6

    

t-B7-H4

  

< 0.001

2.112

1.083–3.960

< 0.001

 Low

52 (44.1)

73.1

    

 High

66 (55.9)

36.4

    

t-COX-2

  

< 0.001

1.886

1.155–2.876

< 0.001

 Low

55 (46.6)

67.3

    

 High

63 (53.4)

39.7

    

s-CEA (ng/ml)

  

< 0.001

2.232

1.187–4.552

< 0.001

 ≤ 4.195

34 (28.8)

67.6

    

 > 4.195

84 (71.2)

46.6

    

s-CA19-9 (U/ml)

  

< 0.001

2.118

1.333–4.237

< 0.001

 ≤ 28.795

47 (39.8)

66.0

    

 > 28.795

71 (60.2)

43.7

    
  1. Univariate analysis showed that tumor size, T stage, N stage, differentiation degree, TNM stage, both serum and tissue IQGAP3, B7-H4 and COX-2 levels and serum CEA and CA19-9 levels were significant prognostic factors for CRC. However, based on multivariate analysis, tumor size was not statistically significant as a prognostic risk factor
  2. LN, lymph nodes; TNM, tumor-node-metastasis; OS, overall survival
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Cancer Cell International

ISSN: 1475-2867

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