Table 1 Logistic regression analysis of associations between genotypes of H19 promoter SNPs and advanced CRC susceptibility
Genotypes | Controls number (%)a | Cases number (%) | P b | Adjusted OR (95% CI)b |
|---|---|---|---|---|
rs4930101 (G/T) | ||||
 TT | 56 (10.09) | 30 (5.24) |  | 1.00 |
 GT | 222 (40.00) | 228 (39.86) | 0.007 | 1.92 (1.19–3.10) |
 GG | 277 (49.91) | 314 (54.90) | 0.001 | 2.12 (1.32–3.39) |
 GT/GG | 499 (89.91) | 542 (94.76) | 0.002 | 2.03 (1.28–3.21) |
 T allele | 334 (30.09) | 288 (25.17) |  | 1.00 |
 G allele | 776 (69.91) | 856 (74.83) | 0.009 | 1.28 (1.06–1.54) |
rs2735970 (G/A) | ||||
 AA | 228 (41.08) | 174 (30.42) |  | 1.00 |
 GA | 242 (43.60) | 302 (52.80) | 0.001 | 1.64 (1.26–2.12) |
 GG | 85 (15.32) | 96 (16.78) | 0.029 | 1.48 (1.04–2.11) |
 GA/GG | 327 (58.92) | 398 (69.58) | 0.001 | 1.60 (1.25–2.04) |
 A allele | 698 (62.88) | 650 (56.82) |  |  |
 G allele | 412 (37.12) | 494 (43.18) | 0.003 | 1.29 (1.09–1.52) |
rs11042170 (G/A) | ||||
 AA | 60 (10.81) | 35 (6.12) |  | 1.00 |
 GA | 226 (40.72) | 223 (38.99) | 0.023 | 1.69 (1.07–2.67) |
 GG | 269 (48.47) | 314 (54.90) | 0.002 | 2.00 (1.28–3.13) |
 GA/GG | 495 (89.19) | 537 (93.88) | 0.005 | 1.86 (1.20–2.87) |
 A allele | 346 (31.17) | 293 (25.61) |  | 1.00 |
 G allele | 764 (68.83) | 851 (74.39) | 0.003 | 1.32 (1.09–1.58) |
Combined effect of risk genotypesc | ||||
 0 | 36 (6.49) | 8 (1.40) |  | 1.00 |
 1 | 162 (29.19) | 127 (22.20) | 0.0012 | 3.53 (1.58–7.86) |
 2 | 133 (23.96) | 298 (52.10) | < 0.0001 | 10.08 (4.56–22.28) |
 3 | 224 (40.36) | 139 (24.30) | 0.0087 | 2.79 (1.26–6.18) |
 ≤ 1 | 36 (6.49) | 8 (1.40) |  | 1.00 |
 > 1 | 519 (93.61) | 564 (98.60) | < 0.0001 | 6.48 (2.97–14.15) |