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Fig. 7 | Cancer Cell International

Fig. 7

From: Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Fig. 7

Combination of Taxol and MCT1 inhibition effectively suppresses Taxol resistant tumor growth in vivo. ac Comparison of tumor volumes in pre-established MCF7 Taxol resistant cells tumor xenografts under treatments with control, Taxol alone (10 mg/kg, i.p., 3 times/wk), Taxol plus SR13800 (10 mg/kg, i.p., 3 times/wk), or Taxol plus miR-124 mimic (5 µL of 50 µM, i.p., 3 times/wk). d MCT1 mRNA expressions in MCF7 Taxol resistant cells tumor xenograft treated with control, Taxol alone, Taxol plus SR13800 and Taxol plus miR-124 mimic. *p < 0.05; **p < 0.01

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