Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms

Table 1 Clinical trials studies on resveratrol and cancer

Cancer	Dose of resveratrol	Duration of study	Number of patient	Outcome	Refs
CRC	5 g/day	14 days	6	Increase the cleaved caspase-3 in malignant hepatic tissue.	[88]
	0.5 or 1 g/day	8 days	20	Decrease expression of Ki-67	[31]
	20 or 80 mg/day	2 weeks	8	Inhibit the Wnt pathway	[100]
PC	150 mg or 1000 mg/day	4 months	66	Decrease the serum levels of androgens with no alterations in prostate tumor growth	[95]
PC	4000 mg/day	4 months	14	Safe	[94]
MM	5 g/day	21 days	24	Unacceptable safety profile and minimal efficacy in patients with relapsed/refractory multiple myeloma highlighting the risks of novel drug development in such populations	[97]
BC	5 or 50 mg twice a day	3 months	39	Reduce the methylation of RASSF-1α	[101]

CRC colorectal cancer, PC prostate cancer, MM multiple myeloma, BC breast cancer

ISSN: 1475-2867