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Table 4 Effect of DOX and/or DIL on serum TAC

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment Total antioxidant capacity (U/ml)
(48 h) (72 h)
Control 27 ± 12 28 ± 3
DIL (4 mg/kg i.p.) 28 ± 3 30 ± 5
DOX (15 mg/kg, i.p.) 13 ± 7a 16 ± 2a
DOX + DIL (administrated simultaneously) 31 ± 5b 30 ± 1b
  1. Data are expressed as mean ± SD of 2 experiments in male Wistar rats after 48 h and 72 h
  2. aSignificantly different from control at p-value < 0.05
  3. bSignificantly different from corresponding DOX at p-value < 0.05