Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Table 4 Effect of DOX and/or DIL on serum TAC

Treatment	Total antioxidant capacity (U/ml)
Treatment	(48 h)	(72 h)
Control	27 ± 12	28 ± 3
DIL (4 mg/kg i.p.)	28 ± 3	30 ± 5
DOX (15 mg/kg, i.p.)	13 ± 7^a	16 ± 2^a
DOX + DIL (administrated simultaneously)	31 ± 5^b	30 ± 1^b

Data are expressed as mean ± SD of 2 experiments in male Wistar rats after 48 h and 72 h
^aSignificantly different from control at p-value < 0.05
^bSignificantly different from corresponding DOX at p-value < 0.05

ISSN: 1475-2867