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Fig. 4 | Cancer Cell International

Fig. 4

From: Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF

Fig. 4

CC-CAFs-derived condition medium promotes migration and adhesion of CRC cells through HGF/MET/AKT signal in colorectal cancer. a Tumor cells were cultured in CC-CAFs-CM for 12 h with or without anti-HGF antibody or c-MET inhibitor SU11274. Protein expression was determined by western blotting and representative results from one of the three independent experiments are presented. b Adhesion assay (top) and migration assay (bottom) in SW48 cells and LOVO with or without anti-HGF antibody or c-MET inhibitor SU11274 (magnification, ×200). The migrated cells and adhered cells was quantified (n = 9). Error bars represent mean ± s.d; *P < 0.05, ***P < 0.001, ****P < 0.0001; by one-way analysis of variance (ANOVA)

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