Fig. 1

miR-125b-5p levels are attenuated in HCC tissues. miR-125b-5p levels in HCC and non-tumor tissues in the a The Cancer Genome Atlas (TCGA) cohort and five Gene Expression Omnibus (GEO) datasets [b GEO series (GSE)10694, c GSE22058, d GSE12717, e GSE21362, and f GSE54751] (P < 0.001, P < 0.001, P < 0.001, P = 0.002, P < 0.001, and P = 0.006, respectively; Student’s t test). miR-125b-5p levels according to qRT-PCR in g an HCC cohort (n = 13; P = 0.006; Student’s t test) and h normal liver cells and HCC cell lines. miR-125b-5p expression is associated with i relapse-free survival of HCC patients in the TCGA cohort and j the overall survival of HCC patients in the GSE10694 dataset (P = 0.027 and P = 0.033, respectively; Kaplan–Meier analysis). k HCC patients exhibiting elevated miR-125b-5p expression showed better overall survival than patients with low miR-125b-5p expression according to gene set enrichment analysis (GSEA) of the TCGA cohort (Enrichment score = 0.803, P < 0.001)