Fig. 8
From: The diverse mechanisms and anticancer potential of naphthoquinones
Representations of the complex human β topoisomerase II, mitoxantrone and DNA (pdb code: 4G0V). a Representation of the view on the side of mitoxantrone which is colored by atomic type. Side chains of the residues highlighted and named with the criterion of distances less than 5Å; DNA in cartoon. b Representation of the top view of mitoxantrone (carbons in green) complexed with DNA and the side chains of the residues (surfaces were calculated according to Sanner et al. [73]). Molecular modeling graphs were produced with the package UCSF Chimera [74]