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Fig. 6 | Cancer Cell International

Fig. 6

From: Long non-coding RNA LINC00485 acts as a microRNA-195 sponge to regulate the chemotherapy sensitivity of lung adenocarcinoma cells to cisplatin by regulating CHEK1

Fig. 6

Restored miR-195 or LINC00485 silencing promotes the inhibitory function of cisplatin on colony formation in LAC cells. a The colony formation rate of A549 cells with intervention of LINC00485; b the colony formation of A549 cells treated by 3 μg/mL cisplatin with intervention of LINC00485; c the colony formation rate of A549 cells with intervention of miR-195; d the colony formation of A549 cells treated by 3 μg/mL cisplatin with intervention of miR-195; e the colony formation rate of A549 cells with intervention of CHEK1; f the colony formation of A549 cells treated by 3 μg/mL cisplatin with intervention of CHEK1; g the colony formation rate of H1299 cells with intervention of LINC00485; h the colony formation of H1299 cells treated by 3 μg/mL cisplatin with intervention of LINC00485; i the colony formation rate of H1299 cells with intervention of miR-195; j the colony formation of H1299 cells treated by 3 μg/mL cisplatin with intervention of miR-195; k the colony formation rate of H1299 cells with intervention of CHEK1; l the colony formation of H1299 cells treated by 3 μg/mL cisplatin with intervention of CHEK1; *p < 0.05 vs. the control; #p < 0.05 vs. cells transfected with blank vector, si-NC, NC and anta-Ctrl. Differences among multiple groups were analyzed by one-way ANOVA. All the experiments were repeated 3 times independently, and the results were expressed as mean ± standard deviation

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Cancer Cell International

ISSN: 1475-2867

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