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Fig. 7 | Cancer Cell International

Fig. 7

From: The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Fig. 7

Graphical abstract of our work. MCL1 protein can be ubiquitinated by several E3 ligases and undergo ubiquitination/proteasome-dependent degradation. Our work uncovered that OTUD1 is a deubiquitinating enzyme of MCL1 and regulates the stability of MCL1 protein. Functional studies indicate that OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through targeting MCL1

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Cancer Cell International

ISSN: 1475-2867

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