Fig. 5
From: miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism
PPARGC1B was involved in miR-21 regulated CD36 expression. a The predicted miR-21 targeting site is present at nucleotide of the 3′ UTR of PPARGC1B. wt, wild-type reporter construct containing PPARGC1B 3′UTR; mut, establishes with mutations in relevant regions; b miR-21 mimic treatment decreased the luciferase activity of PPARGC1B wt, but not mut. c Cells were treated with shPPARGC1B or control, The PPARGC1B expression level was detected. d shPPARGC1B treatment reversed miR-21 inhibitor decreased CD36 expression level. Cells were treated with miR-21 inhibitor or combined shPPARGC1B. The CD36 expression level was detected. *P < 0.05, **P < 0.01