Fig. 7

Schematic diagram of the miR-141/NRP-1 axis in regulating EMT and cell cycle progression. MiR-141 negatively regulates NRP-1 by binding to its 3′-UTR. NRP-1 protein consists of 5 extracellular domains (a1, a2, b1, b2 and c), a transmembrane domain and a short cytosolic tail. “→” indicates promotion, positive regulation or activation; “⊥”, inhibition, negative regulation or blockade. A solid line represents identified mechanisms in the present study, while a dotted line, known mechanisms from previously published studies [9, 10]. “p” indicates phosphorylation of proteins. NRP-1 neuropilin-1, ORF open reading frame, CDK2 cyclin-dependent kinase 2, TGF-β transforming growth factor-β, TGF-βR TGF-β receptor