The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis

Table 1 Summary of the main characteristics of the studies enrolled in the meta-analysis

Study	Year	Country of origin	Tumor type	Sample type	Sample Size	SNHG16 expression		Follow-up months	Detection assay	Clinical stage	Metastasis analysis	Outcome measure	Survival analysis	Cut-off value	Study design	NOS
Study	Year	Country of origin	Tumor type	Sample type	Sample Size	High	Low	Follow-up months	Detection assay	Clinical stage	Metastasis analysis	Outcome measure	Survival analysis	Cut-off value	Study design	NOS
Cao et al.	2017	China	Bladder cancer	Tissue	46	25	21	60	qRT-PCR	N/A	LNM/DM	OS	Univariate	Mean	Cohort study	8
Duan et al.	2016	China	Bladder cancer	Serum	59	N/A	N/A	80	qRT-PCR	N/A	LNM	RFS	Univariate	Median	Cohort study	9
Han et al.	2018	China	Esophageal squamous cell carcinoma	Tissue	128	65	63	60	qRT-PCR	TNM I-IV	LNM	OS	Multivariate	Median	Cohort study	8
Han et al.	2019	China	Non-small cell lung cancer	Tissue	66	33	33	60	qRT-PCR	TNM I-IV	LNM	OS/DFS	Multivariate	Median	Cohort study	8
Lu et al.	2018	China	Glioma	Tissue	48	25	23	60	qRT-PCR	N/A	N/A	OS/PFS	Multivariate	Median	Cohort study	8
Yang et al.	2018	China	Ovarian cancer	Tissue	103	47	56	60	qRT-PCR	FIGO I-IV	DM	OS	Univariate	Mean	Cohort study	8
Zhang et al.	2018	China	Bladder cancer	Serum	74	N/A	N/A	76	qRT-PCR	N/A	LNM	RFS	Univariate	Median	Cohort study	9
Zhu et al.	2018	China	Cervical cancer	Tissue	38	22	16	60	qRT-PCR	FIGO I-III	LNM	OS	Multivariate	Median	Cohort study	8

DFS disease-free survival, DM distant metastasis, FIGO the International Federation of Gynecology and Obstetrics, LNM lymph node metastasis, N/A not available, NOS Newcastle–Ottawa Scale, OS overall survival, PFS progression-free survival, RFS recurrence-free survival, SNHG16 small nucleolar RNA host gene 16, TNM tumor node metastasis

ISSN: 1475-2867