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Fig. 3 | Cancer Cell International

Fig. 3

From: (−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells

Fig. 3

Effects of compound 3, cDDP, or a combination of the two drugs on the cell cycle distribution and proteins associated with cell cycle control in NCI-H441 cells. a The cell cycle distribution (sub-G1, G0/G1, S, and G2/M) was determined by flow cytometry. NCI-H441 cells were treated with various concentrations of compound 3 (0, 50, 100, or 150 μM) or treated with compound 3 and cDDP in combination or individually. b, c The proportions of cells in each phase are expressed as percentages. d The levels of cyclin D1, cyclin E, p53, p21, and PCNA were determined by western blotting with β-tubulin as the loading control. e, f Quantification of relative PCNA and p-p53 protein levels. Data represent the average of three independent experiments (mean ± SD). ***p < 0.001 vs the control; ###p < 0.001, cDDP + compound 3 vs compound 3

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Cancer Cell International

ISSN: 1475-2867

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