miR-190-5p in human diseases

Table 1 Roles of miR-190 and its targets in human cancers

Cancer type	Target genes	Biological function	References
Tumor suppressor
Breast cancer	SMAD2	Inhibiting invasion and metastasis	[12]
	SOX9	Enhancing endocrine therapy sensitivity	[24]
	STC2, PAR1	Inhibiting migration and angiogenesis	[13, 25]
Cervical cancer	–		[23]
Cervical cancer	LNMICC	Inhibiting metastasis	[26]
Colon cancer	HGF, VEGF, JAK2, RAS, SMAD2	Inhibiting angiogenesis	[27]
Glioma	MEF2C	Inhibiting proliferation, migration, and invasion and promoting apoptosis	[20]
Glioma	–	Inhibiting tumor growth	[28]
Hepatocellular carcinoma	treRNA	Inhibiting migration and invasion	[19]
Prostate cancer	YB1	Inhibiting proliferation	[21]
Rectal cancer	–		[22]
Oncogene
Gastric cancer	FOXP2	Promoting proliferation, migration and invasion	[18]
Prostate cancer	PHLPP1	Promoting migration and invasion	[29]
Hepatocellular carcinoma	PHLPP1	Promoting proliferation, migration and invasion	[30]

ISSN: 1475-2867