Fig. 5

CircITCH upregulated HOXB13 expression by sponge miR-17-5p. a Putative binding regions for HOXB13 3′-UTR and miR-17-5p. b Measurement of luciferase activity. c Analysis of HOXB13 mRNA expression levels. d Analysis of HOXB13 protein expression levels. e Correlation analysis of HOXB13 and circITCH in prostate cancer tissues (sample numbers = 52) (r = − 0.508, P < 0.001. *Control group, ^#vs miR-17-5p simulation group. **P < 0.01, ^##P < 0.01