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Fig. 9 | Cancer Cell International

Fig. 9

From: MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells

Fig. 9

NHE1 overexpression promotes MMP3 secretion in MV3 cells. Supernatants of cell cultures were analyzed. a Gelatin degradation assays indicate slight MMP9 and strong pro-MMP9 activity under all conditions examined (NHE1 overexpression, mock control, NHE1 inhibition with cariporide (HOE642)), (N = 3). b Immunoblot analysis shows a strong secretion of MMP3 (~ 54 kDa) in NHE1 overexpressing cells which can be reduced by cariporide (HOE642) (N = 4)

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