Fig. 3

Mixed amphicrine-neuroendocrine carcinoma (case 10). a Admixture of amphicrine carcinoma (upper) and neuroendocrine carcinoma (bottom), in which each constituent was present in equivalent amounts, ×100. b Clusters of disorganized goblet cells in the high-grade amphicrine carcinoma area, ×400. c Neuroendocrine carcinoma component with a traditional small cell carcinoma appearance, ×400. d Positive staining of AE1/AE3 in the amphicrine component, ×200. e Positive staining of synaptophysin in the amphicrine component, ×200. f Immunostaining of Ki67 in the amphicrine component, ×200