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Fig. 5 | Cancer Cell International

Fig. 5

From: LINC01006 promotes cell proliferation and metastasis in pancreatic cancer via miR-2682-5p/HOXB8 axis

Fig. 5

HOXB8 acts as a transcription factor to regulate LINC01006 expression in PC. a RT-qPCR assay was used to detect the overexpression and knockdown efficiency of HOXB8. b It exhibited the DNA motif of the transcription factor, HOXB8. c Luciferase reporter assay confirmed that HOXB8 activated the P2 promoter region activity. d Bioinformatics predicted the potential binding site of HOXB8 in LINC01006 promoter region. e Luciferase reporter assay confirmed that HOXB8 could bind with LINC01006 promoter. f ChIP assay verified the binding ability of HOXB8 in LINC01006 promoter region. *P < 0.05, **P < 0.01

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